bout the principle of Pharmacology
bout the principle of PharmacologyIt is helpful to understand Pharmacology Specialty or those who do not understand pharmacology
One receptor
Receptor 1 is a protein molecule that binds to the cell membrane and reacts with drugs or human physiological signal substances.
This molecule will deform or change its conformation when it combines with the ligand substance, such as drugs or signals, such as hormone molecules.
One part of the receptor is transmembrane structure, that is, the peptide chain with the primary structure of the receptor protein extends into the cell. This part of the peptide chain is very important to combine with the enzyme in the cell, and it is an indispensable part of the physiological and chemical reaction of human body. Two
The conformation of a drug or signal, such as a hormone molecule
In the binding of human physiological signal substances such as hormone molecules or drugs to receptors, the shape of receptors and the basic shape of hormone molecules or drugs are complementary and compatible.
2. Binding conformation
One is that the shape of the receptor is deformed in the binding with hormone molecules or drugs, and the binding conformation can be formed.
3 binding energy, conformational energy
Chemical binding energy is produced in the binding of human physiological signal substances, such as hormone molecules or drugs, to receptors. This energy can make the peptide chain structure of the primary structure of transmembrane receptor protein grow longer and produce binding point with enzymes in cells, which is also releasing chemical energy. The conformation of enzyme protein also produces biochemical change, which is active structure, that is, enzyme protein can release chemical energy, At the same time, it forms a conformational structure that receives cosmic energy.
If ATPase activity is activated by the peptide chain of the primary structure of transmembrane receptor protein, the corresponding signal substance such as hormone binds to the receptor.
If for some reason the signaling material cannot bind to the ATPase receptor, the ATPase cannot be activated and the ATP will not be broken down to produce energy.
So if the Qi of traditional Chinese medicine is ATP, if the reason for the decrease of human energy is the pathological change of its signal such as hormone or receptor, rather than the pathological change of ATPase ATP itself.
The cause of pathological changes in signals such as hormones or receptors
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