It can only show that there are two kinds of binding
Poria cocos has no obvious diuretic effect on healthy people, but has significant diuretic effect on patients with renal and cardiac edema. In recent years, it has been found that Poria cocos has a similar structure to aldosterone and its antagonists. Poria cocos can bind to aldosterone receptor in the serosa of rat renal tubular cells, and antagonize aldosterone activity in vivo,It can only show that there are two kinds of binding receptors in traditional Chinese medicine
If there is a more accurate experimental evidence can be calculated that Chinese medicine can also have the effect of increasing urine in normal people.
It shows that the Chinese medicine also has the binding with the receptor to antagonize the binding of aldosterone with the aldosterone receptor in the cytoplasm of the epithelial cells of the collecting duct and has the effect of increasing urine.
But this does not explain how Poria cocos, a traditional Chinese medicine, can cure oliguria.
Because Poria cocos is not always the same as spironolactone, which is an aldosterone receptor antagonist.
However, the pharmacology of Poria cocos, which actually restores the physiological synthesis of aldosterone, cannot be explained by the pharmacology of spironolactone, an aldosterone receptor antagonist.
It can not be explained by the pharmacological action of ARB, which is an antagonist of tensin Ⅱ receptor, because Poria cocos, a traditional Chinese medicine, can cure oliguria.
The release of aldosterone recovered after a period of treatment, and its plasma concentration may even exceed the baseline level
In addition, the fact also shows that the pathological study does not make clear the whole cause of oliguria in the pathological response of the signal system.
It is not known that there is a change of non physiological structure of aldosterone synthesis receptor in the glomerular zone of adrenal cortex, which can be combined with non physiological signal, non tensin II signal substance, and increase aldosterone synthesis to reduce urinary efflux.
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